Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 6/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 6/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 6/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 6/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 6/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 6/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSPO | P30536 | 3/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5185105 | 0.81 | TSPO (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5186838 | 0.79 | KDM4E (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23148493 | 0.76 | GRIK2 (0.56) | DYRK1AMEN1KMT2APOLBKDM4E | |
| SCHEMBL5185155 | 0.76 | KDM4E (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8867584 | 0.75 | KDM4E (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22873005 | 0.74 | L3MBTL1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28273388 | 0.74 | PSEN1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28948755 | 0.74 | DYRK1A (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8867233 | 0.72 | PSEN1 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5186247 | 0.72 | TSPO (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802299-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | Merck & Co., Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044425-A2 | OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION | MERCK & CO., INC. (US) | 2006-04-27 | — | — | WO | disclosed |