Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3728863 | 0.96 | HCRTR1 (0.65) | HCRTR1HTTKMT2AMEN1KCNQ1 | |
| SCHEMBL8911492 | 0.84 | HCRTR1 (0.55) | HCRTR1HTTALDH1A1GAAMMP8 | |
| SCHEMBL8911495 | 0.84 | HCRTR1 (0.55) | HCRTR1HTTALDH1A1GAAMMP8 | |
| SCHEMBL3441808 | 0.83 | HCRTR1 (0.58) | HCRTR1KMT2AMEN1KCNQ1ALDH1A1 | |
| SCHEMBL4344983 | 0.83 | HCRTR1 (0.52) | HCRTR1KMT2AMEN1KCNQ1ALDH1A1 | |
| SCHEMBL3446571 | 0.83 | HCRTR1 (0.57) | HCRTR1KMT2AMEN1KCNQ1ALDH1A1 | |
| SCHEMBL29783823 | 0.82 | CHRM4 (0.58) | HCRTR1KMT2AMEN1KCNQ1L3MBTL1 | |
| SCHEMBL3441729 | 0.81 | OPRM1 (0.54) | HCRTR1KMT2AMEN1KCNQ1ALDH1A1 | |
| SCHEMBL4436227 | 0.81 | OPRM1 (0.54) | HCRTR1KMT2AMEN1KCNQ1ALDH1A1 | |
| SCHEMBL5173968 | 0.80 | HTT (0.58) | HTTALDH1A1MMP8MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778637-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | Aventis Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006012256-A2 | FKBP BINDING COMPOSITION AND PHARMACEUTICAL USE THEREOF | AVENTIS PHARMACEUTICALS INC. (US) | 2006-02-02 | — | — | WO | disclosed |