Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 4/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL6994474 | 0.85 | GRIA2 (0.38) | GRIA2CA12CA9CA2CA1 | |
| SCHEMBL30184574 | 0.79 | GRIA2 (0.50) | GRIA2CA12CA9CA2CA1 | |
| SCHEMBL22451369 | 0.76 | CA9 (0.42) | CA12CA9CA2CA1CA4 | |
| SCHEMBL21084436 | 0.76 | GRIA2 (0.47) | GRIA2CA12CA9CA2CA1 | |
| SCHEMBL30422601 | 0.76 | GRIA2 (0.47) | GRIA2CA12CA9CA2CA1 | |
| SCHEMBL5186168 | 0.76 | CA12 (0.63) | CA12CA9CA2CA1CA4 | |
| Ethylene SCHEMBL6988767 | 0.75 | L3MBTL1 (0.39) | GRIA2CA12CA9CA2CA1 | |
| SCHEMBL22577967 | 0.73 | KDM4E (0.49) | CA12CA9CA2CA1CA4 | |
| SCHEMBL30718033 | 0.73 | KDM4E (0.49) | CA12CA9CA2CA1CA4 | |
| SCHEMBL26767766 | 0.71 | CA12 (0.56) | CA12CA9CA2CA1CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200299306-A1 | COMPOUNDS WITH A BENZO[A]CARBAZOLE STRUCTURE AND USE THEREOF | UNIVERSITA' DI PISA (IT) | 2020-09-24 | — | — | US | disclosed |
| US-20200299306-A1 | COMPOUNDS WITH A BENZO[A]CARBAZOLE STRUCTURE AND USE THEREOF | UNIVERSITA' DI PISA (IT) | 2020-09-24 | — | — | US | disclosed |
| US-7253161-B2 | Benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2007-08-07 | — | — | US | disclosed |
| US-7250411-B2 | Benzothiazine and benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2007-07-31 | — | — | US | disclosed |
| EP-1456189-B1 | BENZOTHIA(DIA)ZINE DERIVATIVES AND THEIR USE AS AMPA MODULATORS | SERVIER LAB (FR) | 2007-07-04 | — | — | EP | disclosed |
| US-20050124606-A1 | Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-06-09 | — | — | US | disclosed |
| US-20050014744-A1 | Benzothiazine and benzothiadiazine compounds | LES LABORATROIRES SERVIER (FR) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014744-A1 | Benzothiazine and benzothiadiazine compounds | HRH4, NR3C2, HRH3 | GRIA2 316/4885CA12 1277/4885CA9 2714/4885 |
| US-20200299306-A1 | COMPOUNDS WITH A BENZO[A]CARBAZOLE STRUCTURE AND USE THEREOF | MKI67, CCNI, CASP3 | GRIA2 2065/4885CA12 1254/4885CA9 1021/4885 |
| US-20050124606-A1 | Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | NR4A3, NR5A2, NR4A1 | GRIA2 537/4885CA12 3355/4885CA9 4266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.