Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiazolidinedione SCHEMBL6598441 | 0.87 | GSK3A (0.64) | GSK3AGSK3BMGAMGAASI | |
| Hydantoin SCHEMBL11044399 | 0.85 | GSK3A (0.67) | GSK3AGSK3BMGAMGAASI | |
| Hydantoin SCHEMBL5655845 | 0.72 | GSK3A (0.53) | GSK3AGSK3BMGAMGAASI | |
| Thiazolidinedione SCHEMBL8759425 | 0.70 | GSK3A (0.59) | GSK3AGSK3BMGAMGAASI | |
| Thiazolidinedione SCHEMBL4828229 | 0.70 | GSK3A (1.00) | GSK3AGSK3BMGAMGAASI | |
| SCHEMBL4119295 | 0.70 | — | — | |
| SCHEMBL123971 | 0.70 | — | — | |
| Thiazolidinedione SCHEMBL5043 | 0.70 | — | — | |
| Thiazolidinedione SCHEMBL4895522 | 0.70 | — | — | |
| SCHEMBL962066 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756049-A1 | METHOD FOR PRODUCING 1,4-DIPHENYL AZETIDINONE DERIVATIVES | Sanofi-Aventis Deutschland GmbH (DE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005113496-A1 | METHOD FOR PRODUCING 1,4-DIPHENYL AZETIDINONE DERIVATIVES | SANOFI-AVENTIS DEUTSCHLAND GMBH (US) | 2005-12-01 | — | — | WO | disclosed |
| EP-1456187-A4 | N-SUBSTITUTED HETEROCYCLES FOR THE TREATMENT OF HYPERCHOLESTEREMIA, DYSLIPIDEMIA AND OTHER METABOLIC DISORDERS, CANCER, AND OTHER DISEASES | INCYTE SAN DIEGO INC (US) | 2005-02-09 | — | — | EP | disclosed |
| EP-1456187-A1 | N-SUBSTITUTED HETEROCYCLES FOR THE TREATMENT OF HYPERCHOLESTEREMIA, DYSLIPIDEMIA AND OTHER METABOLIC DISORDERS, CANCER, AND OTHER DISEASES | Incyte San Diego Incorporated (US) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003043998-A1 | N-SUBSTITUTED HETEROCYCLES FOR THE TREATMENT OF HYPERCHOLESTEREMIA, DYSLIPIDEMIA AND OTHER METABOLIC DISORDERS, CANCER, AND OTHER DISEASES | INCYTE SAN DIEGO INCORPORATED (US) | 2003-05-30 | — | — | WO | disclosed |