Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.68 |
| ▸ | FLT1 | P17948 | 11/20 | 0.68 |
| ▸ | FLT4 | P35916 | 10/20 | 0.68 |
| ▸ | VCP | P55072 | 2/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.48 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.47 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gw572399X SCHEMBL31060985 | 0.81 | KDR (1.00) | KDRFLT1FLT4VCPROCK1 | |
| Gw549390X SCHEMBL3295009 | 0.77 | KDR (1.00) | KDRFLT1FLT4VCPROCK1 | |
| SCHEMBL5469435 | 0.76 | KDR (0.64) | KDRFLT1FLT4VCPROCK1 | |
| SCHEMBL5477380 | 0.76 | KDR (0.71) | KDRFLT1FLT4VCPROCK1 | |
| SCHEMBL5186212 | 0.74 | KDR (0.61) | KDRFLT1FLT4VCPROCK1 | |
| SCHEMBL15878912 | 0.74 | KDR (0.79) | KDRFLT1FLT4VCPROCK1 | |
| SCHEMBL5319681 | 0.72 | VCP (0.65) | KDRFLT1FLT4VCPROCK1 | |
| SCHEMBL6329220 | 0.70 | KDR (0.79) | KDRFLT1FLT4VCPIMPDH2 | |
| SCHEMBL5473057 | 0.69 | KDR (0.76) | KDRFLT1FLT4VCPIMPDH2 | |
| SCHEMBL5185601 | 0.69 | KDR (0.68) | KDRFLT1FLT4VCPROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551813-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-07-11 | — | — | EP | claimed |
| EP-1551813-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-13 | — | — | EP | claimed |
| WO-2004032882-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-22 | — | — | WO | claimed |