Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 4/20 | 0.65 |
| ▸ | KDR | P35968 | 10/20 | 0.65 |
| ▸ | FLT1 | P17948 | 9/20 | 0.65 |
| ▸ | FLT4 | P35916 | 9/20 | 0.65 |
| ▸ | IMPDH2 | P12268 | 4/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.50 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.50 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.50 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.50 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.50 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.50 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322309 | 0.88 | VCP (0.67) | VCPKDRFLT1FLT4 | |
| Gw549390X SCHEMBL3295009 | 0.80 | KDR (1.00) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL5334357 | 0.77 | KDR (0.69) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL21303737 | 0.77 | VCP (0.66) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL15878912 | 0.76 | KDR (0.79) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL5317562 | 0.76 | VCP (0.61) | VCPKDRFLT1FLT4 | |
| SCHEMBL5475473 | 0.76 | VCP (0.60) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL5480404 | 0.75 | KDR (0.97) | VCPKDRFLT1FLT4IMPDH2 | |
| SCHEMBL8823058 | 0.75 | PTGS2 (0.62) | VCPKDRFLT1FLT4TUBB4A | |
| Gw631581B SCHEMBL5478552 | 0.75 | KDR (1.00) | VCPKDRFLT1FLT4IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076161-A2 | COMPOUNDS WITH THERAPEUTIC ACTIVITY | MYRIAD GENETICS, INC (US) | 2007-07-05 | — | — | WO | disclosed |