Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9260980 | 1.00 | PTPN11 (0.40) | PTPN11NPC1RAB9ATSHRCYP1A2 | |
| SCHEMBL9182173 | 0.89 | RORC (0.40) | PTPN11NPC1RAB9ATSHRCYP1A2 | |
| SCHEMBL9182170 | 0.89 | RORC (0.40) | PTPN11NPC1RAB9ATSHRCYP1A2 | |
| SCHEMBL9269877 | 0.86 | PSEN1 (0.36) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9269874 | 0.86 | PSEN1 (0.36) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL11876698 | 0.85 | MEN1 (0.40) | CYP2C9CYP2C19RORCTDP1MAPT | |
| SCHEMBL9180516 | 0.83 | RORC (0.33) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9180508 | 0.83 | RORC (0.33) | TSHRCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9181799 | 0.83 | PTPN11 (0.43) | PTPN11NPC1RAB9ATSHRCYP1A2 | |
| SCHEMBL9181796 | 0.83 | PTPN11 (0.43) | PTPN11NPC1RAB9ATSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339700-B1 | PROCESS FOR THE PREPARATION OF BENZOTRIAZOLES | CIBA SC HOLDING AG (CH) | 2007-11-21 | — | — | EP | disclosed |
| US-20070208165-A1 | Process for the preparation of benzotriazoles | FISCHER WALTER | 2007-09-06 | — | — | US | disclosed |
| US-20040019220-A1 | Process for the preparation of benzotriazoles | CIBA SPECIALTY CHEMICALS CORP. | 2004-01-29 | — | — | US | disclosed |
| EP-1339700-A1 | PROCESS FOR THE PREPARATION OF BENZOTRIAZOLES | Ciba SC Holding AG (CH) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002024668-A1 | PROCESS FOR THE PREPARATION OF BENZOTRIAZOLES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-03-28 | — | — | WO | disclosed |
| US-5436322-A | Azo coupling of 2-nitroanilines with 2,4,-disbustituted phenols | CIBA-GEIGY CORPORATION (US) | 1995-07-25 | — | — | US | disclosed |
| US-4141903-A | REDUCTION AND CYCLIZATION OF THE CORRESPONDING O-NITROAZOBENZENES WITH CARBON MONOXIDE USING A COPPER-AMINE COMPLEX AS CATALYST | CIBA-GEIGY CORPORATION (US) | 1979-02-27 | — | — | US | disclosed |
| US-3998804-A | PROCESS FOR COUPLING OF WATER-INSOLUBLE 2,4-DISUBSTITUTED PHENOLS WITH DIAZOTIZED O-NITROANILINES | CIBA-GEIGY CORPORATION (US) | 1976-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208165-A1 | Process for the preparation of benzotriazoles | CBR1, CCNT1, CYP1B1 | PTPN11 490/4885NPC1 1954/4885RAB9A 537/4885 |
| US-20040019220-A1 | Process for the preparation of benzotriazoles | SULT1E1, SULT1A1, CYP1B1 | PTPN11 745/4885NPC1 1794/4885RAB9A 842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.