Sugi Predict

Sugi Predict / Compounds / SCHEMBL5186306

SCHEMBL5186306

SCHEMBL5186306

Cc1cc(-c2cccc(NC(=O)Nc3ccc(Cl)cc3)c2)ncn1.O=C(Nc1ccc(Cl)cc1)Nc1ccc(-c2ccccn2)cc1.O=C(Nc1ccc(Cl)cc1)Nc1ccc(-c2ccncc2)cc1.O=C(Nc1ccc(Cl)cc1)Nc1ccc(N2CCCC(O)C2)c(F)c1.O=C(Nc1ccc(Cl)cc1)Nc1cccc(-c2ccnc(N3CCCCC3)n2)c1

nearest known ligand 0.45

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 17/20 0.45
▸ FAAH O00519 1/20 0.44
▸ MAPT P10636 1/20 0.40
▸ MTOR P42345 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5186258 0.84 CNR1 (0.47) CNR1FAAHMAPT
SCHEMBL4913523 0.74 CNR1 (0.73) CNR1FAAHMAPT
SCHEMBL4922538 0.73 CNR1 (0.72) CNR1FAAHMAPT
SCHEMBL4917030 0.71 FPR1 (0.51) CNR1FAAHMAPT
SCHEMBL4922785 0.69 MAPT (0.61) CNR1FAAHMAPT
SCHEMBL5187490 0.69 CNR1 (0.41) CNR1FAAHMAPTMTOR
SCHEMBL4921639 0.68 CNR1 (0.71) CNR1MAPT
SCHEMBL5184609 0.68 MAPT (0.59) CNR1FAAHMAPT
SCHEMBL5187618 0.67 MAPT (0.56) CNR1FAAHMAPT
SCHEMBL5187501 0.67 MAPT (0.65) CNR1FAAHMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1786422-A2 ARYL UREA DERIVATIVES FOR TREATING OBESITY Prosidion Limited (GB) 2007-05-23 — — EP claimed
WO-2006018662-A2 ARYL UREA DERIVATIVES FOR TREATING OBESITY PROSIDION LIMITED (GB) 2006-02-23 — — WO claimed