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SCHEMBL5186258

SCHEMBL5186258

Cc1cc(-c2cccc(NC(=O)Nc3ccc(Cl)cc3)c2)ncn1.O=C(Nc1ccc(Cl)cc1)Nc1ccc(-c2cccnc2)cc1.O=C(Nc1ccc(Cl)cc1)Nc1ccc(N2CCCC(O)C2)c(F)c1

nearest known ligand 0.47

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 9/20 0.47
▸ FPR1 P21462 1/20 0.43
▸ FPR2 P25090 1/20 0.43
▸ FAAH O00519 1/20 0.43
▸ ABL1 P00519 5/20 0.41
▸ MAPT P10636 1/20 0.41
▸ BTK Q06187 2/20 0.41
▸ CNR2 P34972 2/20 0.41
▸ KDR P35968 1/20 0.40
▸ BCR P11274 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5186306 0.84 CNR1 (0.45) CNR1FAAHMAPT
SCHEMBL5186268 0.82 CNR1 (0.69) CNR1MAPTCNR2KDR
SCHEMBL4917030 0.78 FPR1 (0.51) CNR1FPR1FPR2FAAHMAPT
SCHEMBL4921639 0.74 CNR1 (0.71) CNR1MAPTCNR2
SCHEMBL4922088 0.70 FPR1 (0.52) CNR1FPR1FPR2MAPTCNR2
SCHEMBL5186790 0.70 EPHX2 (0.58) CNR1
SCHEMBL4926356 0.69 EPHX2 (0.51) CNR1FPR1FPR2MAPT
SCHEMBL30469259 0.68 CNR1 (1.00) CNR1CNR2KDR
SCHEMBL20557904 0.68 CNR1 (1.00) CNR1CNR2KDR
SCHEMBL1492983 0.67 PORCN (0.69) CNR1MAPTCNR2KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1786422-A2 ARYL UREA DERIVATIVES FOR TREATING OBESITY Prosidion Limited (GB) 2007-05-23 — — EP disclosed
WO-2006018662-A2 ARYL UREA DERIVATIVES FOR TREATING OBESITY PROSIDION LIMITED (GB) 2006-02-23 — — WO disclosed