Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.40 |
| ▸ | RAF1 | P04049 | 3/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699188 | 0.76 | KDM4E (0.45) | MAPK13RAF1MAPK9MAPK12MAPK11 | |
| SCHEMBL4767102 | 0.76 | KDM4E (0.39) | MAPK13RAF1MAPK9MAPK12MAPK11 | |
| SCHEMBL190954 | 0.72 | AURKA (0.63) | AURKAHSP90AA1PRKACAADORA2AKMT2A | |
| SCHEMBL29620532 | 0.72 | AURKA (0.63) | AURKAHSP90AA1PRKACAADORA2AKMT2A | |
| Ammonia Solution, Strong SCHEMBL20267253 | 0.70 | AURKA (0.61) | AURKAHSP90AA1PRKACAADORA2AKMT2A | |
| SCHEMBL29736136 | 0.70 | AURKA (0.61) | AURKAHSP90AA1PRKACAADORA2AKMT2A | |
| SCHEMBL11166709 | 0.70 | NPY5R (0.45) | HSP90AA1KDM4EL3MBTL1RAB9ANPC1 | |
| SCHEMBL5189129 | 0.70 | AURKA (0.44) | AURKAHSP90AA1PRKACAADORA2AMAPK13 | |
| SCHEMBL21003801 | 0.69 | KMT2A (0.61) | AURKAHSP90AA1PRKACAADORA2AKMT2A | |
| SCHEMBL18732403 | 0.69 | KMT2A (0.61) | AURKAHSP90AA1PRKACAADORA2AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805136-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006050097-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2006-05-11 | — | — | WO | claimed |
| US-20060100251-A1 | Substituted phenylalkanoic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-05-11 | — | — | US | claimed |
| US-20040248937-A1 | Substituted phenylalkanoic acids for the treatment of diabetes | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-09 | — | — | US | claimed |
| EP-1805136-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006050097-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060100251-A1 | Substituted phenylalkanoic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-05-11 | — | — | US | disclosed |
| EP-1633354-A2 | N-(((((1,3-THIAZOL-2-YL)AMINO)CARBONYL)PHENYL)SULFONYL)PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-03-15 | — | — | EP | disclosed |
| US-20040248937-A1 | Substituted phenylalkanoic acids for the treatment of diabetes | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-09 | — | — | US | disclosed |
| WO-2004092146-A2 | N- (((((1,3-THIAZOL-2-YL) AMINO) CARBONYL) PHENYL) SULFONYL) PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248937-A1 | Substituted phenylalkanoic acids for the treatment of diabetes | PTP4A1, PTPRJ, PPM1B | AURKA 4131/4885HSP90AA1 975/4885PRKACA 866/4885 |
| US-20060100251-A1 | Substituted phenylalkanoic acids | PTPRJ, PTP4A1, PTPN1 | AURKA 4179/4885HSP90AA1 911/4885PRKACA 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.