Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 3/20 | 0.65 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5187649 | 1.00 | AQP1 (0.65) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4223679 | 0.94 | AQP1 (0.72) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4224942 | 0.94 | AQP1 (0.72) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5186713 | 0.88 | AQP1 (0.65) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5185008 | 0.84 | AQP1 (0.57) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4228615 | 0.84 | AQP1 (0.58) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4228623 | 0.84 | AQP1 (0.58) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL5203385 | 0.82 | AQP1 (0.69) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4225768 | 0.82 | AQP1 (0.69) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL13911343 | 0.81 | AQP1 (0.76) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802598-A2 | ASYMMETRIC SYNTHESIS OF DIHYDROBENZOFURAN DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006047288-A2 | ASYMMETRIC SYNTHESIS OF DIHYDROBENZOFURAN DERIVATIVES | WYETH (US) | 2006-05-04 | — | — | WO | disclosed |
| US-20060089405-A1 | Asymmetric synthesis of dihydrobenzofuran derivatives | WYETH (US) | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089405-A1 | Asymmetric synthesis of dihydrobenzofuran derivatives | DHFR, DHODH, DPYD | AQP1 2577/4885PRKAB2 3831/4885PRKAG1 4373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.