Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT2 | O60551 | 5/20 | 0.44 |
| ▸ | NMT1 | P30419 | 5/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5125338 | 1.00 | NMT2 (0.44) | NMT2NMT1HDAC1HDAC4HDAC6 | |
| SCHEMBL5119081 | 0.85 | CCR8 (0.45) | — | |
| SCHEMBL5119033 | 0.79 | SIGMAR1 (0.49) | HDAC1HDAC4HDAC6HDAC3HDAC2 | |
| SCHEMBL5130543 | 0.78 | HDAC1 (0.51) | NMT2NMT1HDAC1HDAC4HDAC6 | |
| SCHEMBL5121815 | 0.77 | HDAC1 (0.54) | HDAC1HDAC4HDAC6HDAC3HDAC2 | |
| SCHEMBL5126694 | 0.77 | HDAC1 (0.53) | HDAC1HDAC4HDAC6HDAC3HDAC2 | |
| SCHEMBL5127798 | 0.76 | HDAC1 (0.49) | HDAC1HDAC4HDAC6HDAC3HDAC2 | |
| SCHEMBL5125570 | 0.76 | HDAC1 (0.49) | HDAC1HDAC4HDAC6HDAC3HDAC2 | |
| SCHEMBL12488447 | 0.76 | HDAC1 (0.49) | HDAC1HDAC4HDAC6HDAC3HDAC2 | |
| SCHEMBL5164015 | 0.75 | HDAC1 (0.48) | NMT2NMT1HDAC1HDAC4HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768955-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006005941-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI S.P.A. (IT) | 2006-01-19 | — | — | WO | disclosed |