Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.65 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.65 |
| ▸ | CNR2 | P34972 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9790211 | 0.90 | HTT (0.59) | FPR2KMT2AITGB3ITGA2BCNR2 | |
| SCHEMBL9790209 | 0.90 | HTT (0.59) | FPR2KMT2AITGB3ITGA2BCNR2 | |
| SCHEMBL4144668 | 0.88 | ITGB3 (0.65) | ITGB3ITGA2BCNR2CTSLCTSB | |
| SCHEMBL10504767 | 0.88 | ITGB3 (0.65) | ITGB3ITGA2BCNR2CTSLCTSB | |
| SCHEMBL4144665 | 0.88 | ITGB3 (0.65) | ITGB3ITGA2BCNR2CTSLCTSB | |
| SCHEMBL11572546 | 0.88 | FPR2 (0.64) | FPR2KMT2AITGB3ITGA2BCNR2 | |
| SCHEMBL18478934 | 0.87 | LCK (0.61) | FPR2KMT2AITGB3ITGA2BHDAC3 | |
| SCHEMBL9800498 | 0.87 | FPR2 (0.65) | FPR2KMT2AITGB3ITGA2BHDAC3 | |
| SCHEMBL1458952 | 0.86 | PSMB8 (0.67) | KMT2AITGB3ITGA2BCNR2ALDH1A1 | |
| SCHEMBL1459346 | 0.86 | PSMB8 (0.67) | KMT2AITGB3ITGA2BCNR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377542-B1 | HIV PROTEASE INHIBITORS BASED ON AMINO ACID DERIVATIVES | AMBRILIA BIOPHARMA INC (CA) | 2007-08-01 | — | — | EP | disclosed |
| EP-1803706-A1 | HIV protease inhibitors based on amino acid derivatives | Ambrilia Biopharma Inc. (CA) | 2007-07-04 | — | — | EP | disclosed |
| US-7141596-B2 | Inhibitors of proteins that bind phosphorylated molecules | INCYTE CORPORATION (US) | 2006-11-28 | — | — | US | disclosed |
| US-20050272778-A1 | Inhibitors of proteins that bind phosphorylated molecules | INCYTE CORPORATION | 2005-12-08 | — | — | US | disclosed |
| US-6677367-B2 | LYSINE DERIVATIVE WITH 2-AMINOSULFONYLTHIOPHENE SUBSTITUENT; ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) VIRICIDES | PHARMACOR INC. (CA) | 2004-01-13 | — | — | US | disclosed |
| EP-1377542-A1 | HIV PROTEASE INHIBITORS BASED ON AMINO ACID DERIVATIVES | Pharmacor Inc. (CA) | 2004-01-07 | — | — | EP | disclosed |
| US-6656965-B2 | In particular N-epsilon-amino acid substituted L-lysine derivatives possessing aspartyl protease inhibitory properties. | PHARMACOR INC. (CA) | 2003-12-02 | — | — | US | disclosed |
| US-20030195159-A1 | HIV protease inhibitors based on amino acid derivatives | TAIMED BIOLOGICS, INC. (TW) | 2003-10-16 | — | — | US | disclosed |
| US-6610689-B2 | Viricides | PHARMACOR INC. (CA) | 2003-08-26 | — | — | US | disclosed |
| US-6608100-B1 | N-epsilon-amino acid substituted L-lysine sulfonamide derivatives possessing aspartyl protease inhibitory properties | PHARMACOR INC. (CA) | 2003-08-19 | — | — | US | disclosed |
| US-20030144265-A1 | HIV protease inhibitors based on amino acid derivatives | TAIMED BIOLOGICS, INC. (TW) | 2003-07-31 | — | — | US | disclosed |
| US-20030119803-A1 | HIV protease inhibitors based on amino acid derivatives | TAIMED BIOLOGICS, INC. (TW) | 2003-06-26 | — | — | US | disclosed |
| US-6506786-B2 | Such as N-isobutyl-N-(4-methylbenzene-sulfonyl)-N-(N-(4-methylbenzenesulfonyl)-L -phenylalanyl)-L-lysine | PHARMACOR INC. (CA) | 2003-01-14 | — | — | US | disclosed |
| US-20020151546-A1 | HIV protease inhibitors based on amino acid derivatives | TAIMED BIOLOGICS, INC. (TW) | 2002-10-17 | — | — | US | disclosed |
| WO-2002064551-A1 | HIV PROTEASE INHIBITORS BASED ON AMINO ACID DERIVATIVES | PHARMACOR INC. (CA) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144265-A1 | HIV protease inhibitors based on amino acid derivatives | ANPEP, PEPD, XPNPEP1 | FPR2 1026/4885KMT2A 906/4885ITGB3 2667/4885 |
| US-20020151546-A1 | HIV protease inhibitors based on amino acid derivatives | ANPEP, PEPD, XPNPEP1 | FPR2 1026/4885KMT2A 906/4885ITGB3 2667/4885 |
| US-20030195159-A1 | HIV protease inhibitors based on amino acid derivatives | ANPEP, PEPD, XPNPEP1 | FPR2 1026/4885KMT2A 906/4885ITGB3 2667/4885 |
| US-20050272778-A1 | Inhibitors of proteins that bind phosphorylated molecules | PPP3CA, PPP5C, PPM1A | FPR2 3422/4885KMT2A 3697/4885ITGB3 3183/4885 |
| US-20030119803-A1 | HIV protease inhibitors based on amino acid derivatives | ANPEP, PEPD, XPNPEP1 | FPR2 1026/4885KMT2A 906/4885ITGB3 2667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.