Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19323015 | 0.80 | CYP2A6 (0.46) | MAPK1KDM4EALDH1A1CYP19A1CYP3A4 | |
| SCHEMBL14736755 | 0.80 | MAPK1 (0.44) | MAPK1KDM4EALDH1A1KMOMAPT | |
| SCHEMBL8219898 | 0.79 | GRK6 (0.46) | MAPK1KDM4EKMOPOLBMAPT | |
| SCHEMBL5191848 | 0.78 | MAPK1 (0.42) | MAPK1ALDH1A1KMOCYP19A1MKNK1 | |
| SCHEMBL7686070 | 0.78 | MAPK1 (0.43) | MAPK1ALDH1A1CYP19A1MKNK1MKNK2 | |
| SCHEMBL5025500 | 0.78 | MAPK1 (0.43) | MAPK1ALDH1A1CYP19A1MKNK1MKNK2 | |
| SCHEMBL27515966 | 0.77 | KMO (0.51) | MAPK1KDM4EALDH1A1KMOCYP19A1 | |
| SCHEMBL7066160 | 0.77 | MAPK1 (0.43) | MAPK1ALDH1A1MAPTCYP19A1MKNK1 | |
| SCHEMBL455756 | 0.75 | MAPK1 (0.42) | MAPK1ALDH1A1CYP19A1MKNK1MKNK2 | |
| SCHEMBL1133233 | 0.75 | CYP2A6 (0.47) | MAPK1ALDH1A1CYP19A1CYP3A4CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363925-B8 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LTD (GB) | 2007-04-25 | — | — | EP | disclosed |
| EP-1471923-A4 | AMIDO MACROLIDES | KOSAN BIOSCIENCES INC (US) | 2006-01-11 | — | — | EP | disclosed |
| EP-1471923-A1 | AMIDO MACROLIDES | Kosan Biosciences, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| EP-1363925-A1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LIMITED (GB) | 2003-11-26 | — | — | EP | disclosed |
| WO-2003061671-A1 | AMIDO MACROLIDES | KOSAN BIOSCIENCES, INC. (US) | 2003-07-31 | — | — | WO | disclosed |
| WO-2002050091-A1 | MACROLIDE ANTIBIOTICS | GLAXO GROUP LIMITED (GB) | 2002-06-27 | — | — | WO | disclosed |