Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 18/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5195449 | 0.85 | PYGL (0.59) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5195453 | 0.85 | PYGL (0.59) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5427731 | 0.85 | PYGL (0.48) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5196225 | 0.84 | PYGL (0.53) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5196236 | 0.84 | PYGL (0.53) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5192639 | 0.83 | PYGL (0.57) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5197590 | 0.83 | PYGL (0.48) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5197602 | 0.83 | PYGL (0.48) | PYGLCNR1CNR2CYP2C9 | |
| SCHEMBL5191876 | 0.82 | PYGL (0.62) | PYGLCYP2C9NPC1 | |
| Hydrochloric Acid SCHEMBL5192284 | 0.81 | PYGL (0.61) | PYGLCYP2C9NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |