Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27712439 | 0.83 | THRB (0.40) | THRBBRD4TDP1L3MBTL1KMT2A | |
| SCHEMBL31645448 | 0.83 | BRD4 (0.49) | THRBBRD4TDP1L3MBTL1KMT2A | |
| SCHEMBL337398 | 0.83 | BRD4 (0.49) | THRBBRD4TDP1L3MBTL1KMT2A | |
| SCHEMBL30045918 | 0.83 | BRD4 (0.49) | THRBBRD4TDP1L3MBTL1KMT2A | |
| SCHEMBL5195719 | 0.79 | KMT2A (0.43) | L3MBTL1KMT2AALDH1A1CTSSCTSK | |
| SCHEMBL10413120 | 0.78 | BRD4 (0.47) | THRBBRD4TDP1L3MBTL1KMT2A | |
| SCHEMBL9458900 | 0.77 | THRB (0.43) | THRBTDP1L3MBTL1KMT2AALDH1A1 | |
| SCHEMBL15236714 | 0.74 | THRB (0.41) | THRBTDP1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL8177320 | 0.74 | THRB (0.41) | THRBTDP1ALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL30772808 | 0.73 | DRD2 (0.46) | THRBTDP1KMT2AALDH1A1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006052722-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |