Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | PRCP | P42785 | 3/20 | 0.41 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212907 | 0.85 | PRCP (0.54) | EPHX1PRCPEPHX2NAAA | |
| SCHEMBL25022177 | 0.82 | PRCP (0.61) | EPHX1PRCPEPHX2NAAA | |
| SCHEMBL2240203 | 0.77 | OTC (0.47) | FDPSMAPK11MAPK14CYP2D6MEN1 | |
| SCHEMBL28102652 | 0.77 | OTC (0.47) | FDPSMAPK11MAPK14CYP2D6MEN1 | |
| SCHEMBL6050265 | 0.76 | FDPS (0.44) | EPHX1PRCPFDPSCYP2D6MEN1 | |
| SCHEMBL2236439 | 0.73 | FDPS (0.39) | FDPSEPHX2CYP2D6MEN1ALDH1A1 | |
| SCHEMBL28095715 | 0.73 | FDPS (0.39) | FDPSEPHX2CYP2D6MEN1ALDH1A1 | |
| SCHEMBL5372949 | 0.73 | FDPS (0.46) | FDPSCYP2D6MEN1ALDH1A1LMNA | |
| SCHEMBL2235726 | 0.72 | OTC (0.48) | PRCPFDPSMAPK11MAPK14 | |
| SCHEMBL28102738 | 0.72 | OTC (0.48) | PRCPFDPSMAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |