Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193866 | 0.82 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL4816894 | 0.82 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL4816890 | 0.82 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL5191123 | 0.82 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL5189871 | 0.81 | MAOB (0.59) | MAOBNR4A2NPC1RAB9ABCHE | |
| SCHEMBL4824587 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL4824599 | 0.79 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DNPC1 | |
| SCHEMBL13984813 | 0.78 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13986023 | 0.78 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4818836 | 0.70 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799634-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006026747-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2006-03-09 | — | — | WO | disclosed |