Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26024360 | 0.89 | HRH3 (0.60) | HRH3SIGMAR1TDP1HCRTR1HCRTR2 | |
| SCHEMBL5195350 | 0.86 | HRH3 (0.56) | HRH3SIGMAR1DRD2 | |
| SCHEMBL6802071 | 0.85 | HRH3 (0.66) | HRH3SIGMAR1TDP1 | |
| SCHEMBL6802079 | 0.85 | HRH3 (0.66) | HRH3SIGMAR1TDP1 | |
| SCHEMBL5191198 | 0.84 | MAPK1 (0.56) | SIGMAR1TDP1HCRTR1HCRTR2DRD2 | |
| SCHEMBL8938433 | 0.80 | HRH3 (0.69) | HRH3SIGMAR1TDP1 | |
| SCHEMBL9752686 | 0.78 | HRH3 (0.69) | HRH3SIGMAR1 | |
| SCHEMBL5195704 | 0.77 | SPHK2 (0.52) | SIGMAR1 | |
| SCHEMBL26024361 | 0.76 | TDP1 (0.51) | HRH3SIGMAR1TDP1 | |
| SCHEMBL5193949 | 0.76 | OPRD1 (0.45) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |