Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MDH2 | P40926 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4960099 | 0.87 | HTT (0.39) | HTTALDH1A1HPGDMDH2SMN1; SMN2 | |
| SCHEMBL4960348 | 0.87 | HTT (0.40) | HTTALDH1A1HPGDMDH2SMN1; SMN2 | |
| SCHEMBL5194886 | 0.85 | HTT (0.45) | HTTALDH1A1HPGDMDH2SMN1; SMN2 | |
| SCHEMBL4961058 | 0.84 | HTT (0.40) | HTTALDH1A1HPGDMDH2SMN1; SMN2 | |
| SCHEMBL4963693 | 0.83 | HTT (0.39) | HTTALDH1A1HPGDMDH2SMN1; SMN2 | |
| SCHEMBL4961388 | 0.82 | HTT (0.40) | HTTALDH1A1HPGDMDH2SMN1; SMN2 | |
| SCHEMBL3816049 | 0.79 | GABRA1 (0.48) | HTTKDM4E | |
| SCHEMBL4980763 | 0.74 | HTT (0.35) | HTTALDH1A1HPGDMDH2SMN1; SMN2 | |
| SCHEMBL4963341 | 0.72 | HTT (0.46) | HTTALDH1A1HPGDMDH2SMN1; SMN2 | |
| SCHEMBL4962848 | 0.72 | HTT (0.47) | HTTALDH1A1HPGDMDH2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756135-A1 | ESTER LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005108412-A1 | ESTER LINKED MACROLIDES USEFUL FOR THE TREATMENT OF MICROBIAL INFECTIONS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (US) | 2005-11-17 | — | — | WO | disclosed |