Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4526090 | 0.96 | OPRM1 (0.42) | NPC1RAB9AOPRK1KCNH2OPRM1 | |
| SCHEMBL4519364 | 0.92 | RAB9A (0.46) | NPC1RAB9AOPRK1KCNH2OPRM1 | |
| SCHEMBL4527906 | 0.84 | RAB9A (0.49) | NPC1RAB9AOPRK1KCNH2OPRM1 | |
| SCHEMBL4509023 | 0.84 | RAB9A (0.40) | NPC1RAB9AROCK2KMT2APDK2 | |
| SCHEMBL4503442 | 0.82 | OPRM1 (0.41) | NPC1RAB9AOPRK1KCNH2OPRM1 | |
| SCHEMBL4519685 | 0.78 | OPRM1 (0.43) | OPRK1KCNH2OPRM1KMT2AOPRD1 | |
| SCHEMBL4505597 | 0.76 | OPRM1 (0.40) | OPRK1KCNH2OPRM1KMT2AOPRD1 | |
| SCHEMBL4504977 | 0.76 | PDK2 (0.43) | NPC1RAB9AROCK2KMT2AHPGD | |
| SCHEMBL5097179 | 0.76 | NPC1 (0.51) | NPC1RAB9AOPRK1KCNH2OPRM1 | |
| SCHEMBL5097505 | 0.76 | NPC1 (0.51) | NPC1RAB9AOPRK1KCNH2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833825-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-19 | — | — | EP | claimed |
| WO-2006069277-A1 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | claimed |