Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 5/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | GUSB | P08236 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 5/20 | 0.32 |
| ▸ | HTR2C | P28335 | 5/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513007 | 0.87 | OPRM1 (0.42) | OPRD1OPRM1HPGDGUSBUSP2 | |
| SCHEMBL4514324 | 0.76 | OPRD1 (0.42) | OPRD1OPRM1HPGDHTR2AHTR2C | |
| SCHEMBL4507748 | 0.76 | OPRD1 (0.50) | OPRD1OPRM1HPGDUSP2MEN1 | |
| SCHEMBL4507471 | 0.72 | OPRD1 (0.47) | OPRD1OPRM1HPGDGUSBUSP2 | |
| SCHEMBL4517006 | 0.69 | OPRD1 (0.45) | OPRD1OPRM1HPGDMEN1POLB | |
| SCHEMBL4519813 | 0.69 | OPRD1 (0.45) | OPRD1OPRM1HPGDMEN1POLB | |
| SCHEMBL5196626 | 0.69 | OPRD1 (0.43) | OPRD1OPRM1HPGDMEN1KMT2A | |
| SCHEMBL4518730 | 0.69 | OPRD1 (0.44) | OPRD1OPRM1HPGDMEN1POLB | |
| SCHEMBL490270 | 0.68 | OPRD1 (0.48) | OPRD1OPRM1USP2MEN1KMT2A | |
| SCHEMBL4511427 | 0.67 | OPRM1 (0.43) | OPRD1OPRM1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833825-A1 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-19 | — | — | EP | claimed |
| WO-2006069277-A1 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | claimed |