Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26080896 | 0.86 | ALOX5 (0.56) | ALOX5GRM5CYP2A6MGLLBCL2L1 | |
| SCHEMBL12884269 | 0.76 | GRM5 (0.60) | ALOX5GRM5CYP2A6MGLLBCL2L1 | |
| SCHEMBL9049119 | 0.76 | ALOX5 (1.00) | ALOX5ACACBCYP1A2PTGESLMNA | |
| SCHEMBL12884270 | 0.74 | GRM5 (0.58) | ALOX5GRM5CYP2A6MGLLBCL2L1 | |
| SCHEMBL12884267 | 0.73 | GRM5 (0.57) | ALOX5GRM5CYP2A6MGLLBCL2L1 | |
| SCHEMBL4807743 | 0.72 | GRM5 (0.60) | ALOX5GRM5CYP2A6MGLLBCL2L1 | |
| SCHEMBL9203796 | 0.71 | GRM5 (0.59) | ALOX5GRM5CYP2A6MGLLBCL2L1 | |
| SCHEMBL1444769 | 0.69 | ALOX5 (0.55) | ALOX5CYP2A6CYP1A2PTGESLMNA | |
| SCHEMBL9208830 | 0.69 | GRM5 (0.53) | ALOX5GRM5CYP2A6MGLLBCL2L1 | |
| SCHEMBL12083710 | 0.69 | TSHR (0.47) | ALOX5CYP1A2LMNAGAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812387-A1 | 2,3,4-SUBSTITUTED CYCLOPENTANONES AS THERAPEUTIC AGENTS | Allergan, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006055481-A1 | 2,3,4-SUBSTITUTED CYCLOPENTANONES AS THERAPEUTIC AGENTS | ALLERGAN , INC. (US) | 2006-05-26 | — | — | WO | disclosed |