Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.31 |
| ▸ | HPGD | P15428 | 4/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15759413 | 0.74 | LOXL2 (0.44) | LOXL2PTGER4ALDH1A1HPGDNPC1 | |
| SCHEMBL662349 | 0.73 | LOXL2 (0.41) | LOXL2PTGER4ALDH1A1HPGDNPC1 | |
| SCHEMBL13143573 | 0.71 | LOXL2 (0.61) | LOXL2ALDH1A1HPGDTP53MAPT | |
| SCHEMBL17256159 | 0.70 | LOXL2 (0.43) | LOXL2PTGER4ALDH1A1HPGDNPC1 | |
| SCHEMBL660560 | 0.69 | LOXL2 (0.39) | LOXL2PTGER4ALDH1A1HPGDNPC1 | |
| SCHEMBL660561 | 0.69 | LOXL2 (0.39) | LOXL2PTGER4ALDH1A1HPGDNPC1 | |
| SCHEMBL5196496 | 0.67 | AGXT (0.46) | LOXL2ASIC3 | |
| SCHEMBL17256209 | 0.66 | LOXL2 (0.41) | LOXL2PTGER4ALDH1A1HPGDNPC1 | |
| SCHEMBL17256208 | 0.66 | LOXL2 (0.41) | LOXL2PTGER4ALDH1A1HPGDNPC1 | |
| SCHEMBL13179819 | 0.65 | LOXL2 (0.61) | LOXL2ALDH1A1HPGDMAPTCD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814848-A1 | 2,3,4-SUBSTITUTED-CYCLOPENTANONES AS THERAPEUTIC AGENTS | Allergan, Inc. (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1812387-A1 | 2,3,4-SUBSTITUTED CYCLOPENTANONES AS THERAPEUTIC AGENTS | Allergan, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006058063-A1 | 2,3,4-SUBSTITUTED-CYCLOPENTANONES AS THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2006-06-01 | — | — | WO | disclosed |
| WO-2006055481-A1 | 2,3,4-SUBSTITUTED CYCLOPENTANONES AS THERAPEUTIC AGENTS | ALLERGAN , INC. (US) | 2006-05-26 | — | — | WO | disclosed |