Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 8/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5194021 | 0.88 | SIGMAR1 (0.54) | DRD4DRD2DRD3SIRT2SIRT1 | |
| SCHEMBL12696683 | 0.88 | DRD4 (0.55) | DRD4SMN1; SMN2GRIN2BKDM4E | |
| SCHEMBL12696708 | 0.84 | DRD4 (0.54) | DRD4DRD2DRD3TSHRGRIN2B | |
| SCHEMBL12696566 | 0.82 | DRD4 (0.56) | DRD4DRD2DRD3SIRT1GRIN2B | |
| SCHEMBL2447401 | 0.82 | DRD4 (0.56) | DRD4DRD2DRD3SIRT1GRIN2B | |
| SCHEMBL14357562 | 0.82 | DRD4 (0.62) | DRD4DRD2DRD3TSHRGRIN2B | |
| SCHEMBL8329098 | 0.79 | DRD4 (0.74) | DRD4SMN1; SMN2DRD2DRD3 | |
| SCHEMBL20945053 | 0.79 | DRD4 (0.74) | DRD4SMN1; SMN2DRD2DRD3 | |
| SCHEMBL8327676 | 0.77 | DRD4 (0.64) | DRD4SMN1; SMN2DRD2DRD3TSHR | |
| SCHEMBL14388375 | 0.77 | DRD4 (0.62) | DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |