Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3167855 | 0.91 | HRH3 (0.37) | HRH3DRD2DRD4OPRM1OPRD1 | |
| SCHEMBL13395081 | 0.91 | HRH3 (0.37) | HRH3DRD2DRD4OPRM1OPRD1 | |
| SCHEMBL3177398 | 0.89 | CYP11B1 (0.40) | CYP11B1CYP11B2HRH3GSK3BDRD2 | |
| SCHEMBL13394862 | 0.89 | CYP11B1 (0.40) | CYP11B1CYP11B2HRH3GSK3BDRD2 | |
| SCHEMBL13394898 | 0.89 | CYP11B1 (0.40) | CYP11B1CYP11B2HRH3GSK3BDRD2 | |
| SCHEMBL5197806 | 0.88 | HCRTR1 (0.39) | CYP11B1CYP11B2HRH3DRD2DRD4 | |
| SCHEMBL13395065 | 0.85 | OPRM1 (0.37) | CYP11B1CYP11B2OPRM1BRD4KCNH2 | |
| SCHEMBL3173482 | 0.85 | OPRM1 (0.37) | CYP11B1CYP11B2OPRM1BRD4KCNH2 | |
| SCHEMBL4519661 | 0.82 | HRH3 (0.35) | CYP11B1CYP11B2HRH3GSK3BDRD2 | |
| SCHEMBL3188918 | 0.81 | CYP11B2 (0.39) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833826-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006069276-A2 | TRICYCLIC ō-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | disclosed |