Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202400 | 0.88 | MAPT (0.46) | GPR119MAPTKDM1AKDM4EPKM | |
| SCHEMBL5199823 | 0.88 | KDM1A (0.43) | GPR119KDM1AKDM4EPKMALDH1A1 | |
| SCHEMBL16825244 | 0.84 | GPR119 (0.60) | GPR119MAPTSMN1; SMN2KDM1AKDM1B | |
| SCHEMBL8111261 | 0.75 | GPR119 (0.49) | GPR119MAPTSMN1; SMN2KDM1AKDM1B | |
| SCHEMBL18280173 | 0.75 | KDM4E (0.56) | GPR119MAPTSMN1; SMN2DPP4KDM4E | |
| SCHEMBL376926 | 0.74 | GPR119 (0.48) | GPR119MAPTSMN1; SMN2KDM1AKDM1B | |
| SCHEMBL8116325 | 0.74 | GPR119 (0.51) | GPR119MAPTSMN1; SMN2KDM1AKDM1B | |
| SCHEMBL20015328 | 0.74 | GPR119 (0.59) | GPR119MAPTSMN1; SMN2KDM1AKDM1B | |
| SCHEMBL14306310 | 0.74 | KDM1A (0.48) | GPR119MAPTSMN1; SMN2KDM1AKDM1B | |
| SCHEMBL4680824 | 0.73 | KDM4E (0.57) | GPR119MAPTSMN1; SMN2KDM1AKDM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765778-A2 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005117543-A2 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-12-15 | — | — | WO | disclosed |