Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DTYMK | P23919 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197385 | 0.88 | GPR119 (0.48) | KDM1AKDM4EPKMGPR119CHRM2 | |
| SCHEMBL5202400 | 0.88 | MAPT (0.46) | KDM1AKDM4EPKMGPR119CHRM2 | |
| SCHEMBL15684511 | 0.78 | KDM4E (0.51) | KDM1AKDM4EPKMGPR119STS | |
| SCHEMBL376786 | 0.74 | KDM1A (0.45) | KDM1AKDM4EPKMGPR119CHRM2 | |
| SCHEMBL376336 | 0.73 | ALDH1A1 (0.60) | KDM1AKDM4ECHRM2CHRM4CHRM1 | |
| SCHEMBL23119230 | 0.72 | KDM4E (0.55) | KDM4EPKMGPR119ALDH1A1 | |
| SCHEMBL21383697 | 0.72 | PKM (0.55) | KDM1AKDM4EPKMGPR119 | |
| SCHEMBL1405373 | 0.72 | KDM4E (0.57) | KDM1AKDM4EPKMGPR119CHRM2 | |
| SCHEMBL1475518 | 0.71 | STS (0.51) | KDM1AKDM4EPKMGPR119STS | |
| SCHEMBL25471671 | 0.71 | CARM1 (0.53) | KDM1AKDM4EPKMGPR119STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765778-A2 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005117543-A2 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-12-15 | — | — | WO | disclosed |