Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.41 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221990 | 0.92 | MEN1 (0.49) | OPRM1KMT2AMEN1RAB9AOPRD1 | |
| SCHEMBL3015083 | 0.89 | MEN1 (0.43) | OPRM1KMT2AMEN1RAB9AOPRD1 | |
| SCHEMBL4870754 | 0.86 | TET3 (0.50) | OPRM1SIGMAR1KMT2AHSD11B1TET3 | |
| SCHEMBL4879638 | 0.84 | APP (0.43) | OPRM1KMT2AHSD11B1TET3FBXL19 | |
| SCHEMBL4873237 | 0.78 | HSD11B1 (0.43) | OPRM1KMT2AMEN1RAB9AHSD11B1 | |
| SCHEMBL119410 | 0.78 | KMT2A (0.49) | OPRM1KMT2AMEN1RAB9AHSD11B1 | |
| SCHEMBL22960725 | 0.75 | KMT2A (0.42) | OPRM1KMT2AMEN1RAB9ALMNA | |
| SCHEMBL30089214 | 0.75 | KMT2A (0.42) | OPRM1KMT2AMEN1RAB9ALMNA | |
| SCHEMBL3015079 | 0.75 | KMT2A (0.42) | OPRM1KMT2AMEN1RAB9AHSD11B1 | |
| SCHEMBL3219970 | 0.75 | FABP5 (0.49) | KMT2ARAB9ALMNAOPRD1FABP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814552-A2 | COMPOUNDS FOR TREATING PROTEIN-KINASE MEDIATED DISORDERS | Astex Therapeutics Limited (GB) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006051290-A2 | COMPOUNDS FOR TREATING PROTEIN-KINASE MEDIATED DISORDERS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-05-18 | — | — | WO | disclosed |