Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5119580 | 0.74 | BCHE (0.44) | OPRM1OPRD1BCHEGAAMAPT | |
| SCHEMBL3173021 | 0.73 | OPRM1 (0.48) | OPRM1OPRD1BCHEGAAMAPT | |
| SCHEMBL5119371 | 0.68 | OPRM1 (0.47) | OPRM1OPRD1BCHEGAAMAPT | |
| SCHEMBL3583913 | 0.66 | MAPT (0.66) | GAAMAPTMEN1KMT2ALMNA | |
| SCHEMBL13846961 | 0.65 | CYP1A2 (0.43) | OPRM1BCHEGAAMAPTMEN1 | |
| SCHEMBL27840689 | 0.63 | LMNA (0.59) | OPRM1GAAMAPTMEN1KMT2A | |
| SCHEMBL6308837 | 0.62 | OPRM1 (1.00) | OPRM1OPRD1 | |
| SCHEMBL18381732 | 0.62 | TP53 (0.67) | GAAMAPTMEN1KMT2ALMNA | |
| SCHEMBL9784961 | 0.62 | TP53 (0.48) | OPRM1BCHEGAAMAPTMEN1 | |
| SCHEMBL9784967 | 0.62 | TP53 (0.48) | OPRM1BCHEGAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833826-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006069276-A2 | TRICYCLIC ō-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | disclosed |