Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 8/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.48 |
| ▸ | HRH1 | P35367 | 3/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203152 | 0.85 | TMEM97 (0.63) | ABHD6TMEM97SIGMAR1HRH1HRH3 | |
| SCHEMBL8203214 | 0.84 | ABHD6 (0.60) | ABHD6KDM4ETMEM97SIGMAR1HRH1 | |
| SCHEMBL3878092 | 0.80 | ABHD6 (0.68) | ABHD6TMEM97SIGMAR1HRH1HRH3 | |
| SCHEMBL20983790 | 0.79 | ABHD6 (1.00) | ABHD6 | |
| SCHEMBL8264115 | 0.72 | KDM4E (0.46) | ABHD6KDM4ESIGMAR1HTR1AHTR2A | |
| Hydrochloric Acid SCHEMBL3872400 | 0.71 | ABHD6 (0.45) | ABHD6KDM4EHTR2CFAAHALDH1A1 | |
| SCHEMBL23701437 | 0.70 | KDM4E (0.55) | ABHD6KDM4EFAAHALDH1A1 | |
| SCHEMBL14959461 | 0.70 | TMEM97 (0.66) | ABHD6TMEM97SIGMAR1HRH1HRH3 | |
| SCHEMBL327254 | 0.69 | KDM4E (1.00) | KDM4EFAAHALDH1A1 | |
| SCHEMBL3823637 | 0.69 | KDM4E (0.58) | ABHD6KDM4EFAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848694-A1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | F. Hoffmann-Roche AG (CH) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006082001-A1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |