Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.50 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.49 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322318 | 0.90 | ALDH1A1 (0.58) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL6678912 | 0.82 | HTT (0.58) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL6678910 | 0.82 | HTT (0.58) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL5680449 | 0.81 | HTT (0.53) | ALDH1A1HTTMEN1KMT2ATAS1R3 | |
| SCHEMBL27562830 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HTTMEN1KMT2AUSP2 | |
| SCHEMBL5653436 | 0.79 | ALDH1A1 (0.64) | ALDH1A1HTTMEN1KMT2AUSP2 | |
| SCHEMBL5653425 | 0.79 | ALDH1A1 (0.64) | ALDH1A1HTTMEN1KMT2AUSP2 | |
| SCHEMBL14335070 | 0.77 | HTT (0.63) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL10159937 | 0.77 | PDPK1 (0.53) | ALDH1A1HTTMEN1KMT2AUSP2 | |
| SCHEMBL13164295 | 0.77 | PDPK1 (0.53) | ALDH1A1HTTMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799637-A1 | SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE | Amgen, Inc (US) | 2007-06-27 | — | — | EP | claimed |
| WO-2006036664-A1 | SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | claimed |