Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | ACE | P12821 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.47 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198356 | 0.90 | ALDH1A1 (0.61) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL6678910 | 0.80 | HTT (0.58) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL6678912 | 0.80 | HTT (0.58) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL4739536 | 0.80 | ACE (0.49) | ALDH1A1ACEMEN1KMT2AKDM4E | |
| SCHEMBL4739541 | 0.80 | ACE (0.49) | ALDH1A1ACEMEN1KMT2AKDM4E | |
| SCHEMBL5127845 | 0.80 | ACE (0.49) | ALDH1A1ACEMEN1KMT2AKDM4E | |
| SCHEMBL14335648 | 0.79 | HTT (0.64) | ALDH1A1HTTMEN1KMT2ATAS1R3 | |
| SCHEMBL14376818 | 0.79 | HTT (0.64) | ALDH1A1HTTMEN1KMT2ATAS1R3 | |
| SCHEMBL29649170 | 0.77 | ACE (0.47) | ACE | |
| SCHEMBL5653436 | 0.77 | ALDH1A1 (0.64) | ALDH1A1HTTMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856074-A2 | SUBSTITUTED ARYL OR HETEROARYLSULFONYLBUTANAMIDES FOR USE AS ANTI-INFLAMMATORY AGENTS | Amgen, Inc (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006041888-A2 | SUBSTITUTED ARYL OR HETEROARYLSULFONYLBUTANAMIDES FOR USE AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 2006-04-20 | — | — | WO | claimed |
| EP-1856074-A2 | SUBSTITUTED ARYL OR HETEROARYLSULFONYLBUTANAMIDES FOR USE AS ANTI-INFLAMMATORY AGENTS | Amgen, Inc (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006041888-A2 | SUBSTITUTED ARYL OR HETEROARYLSULFONYLBUTANAMIDES FOR USE AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 2006-04-20 | — | — | WO | disclosed |