Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.42 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LSS | P48449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200392 | 0.89 | MAPK14 (0.41) | AAK1AKT1MAPK14MAPK13MAPK12 | |
| SCHEMBL5199937 | 0.87 | MAPK14 (0.42) | AAK1AKT1MAPK14MAPK13MAPK12 | |
| SCHEMBL5196936 | 0.80 | MAPK14 (0.40) | AKT1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5199024 | 0.78 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5197184 | 0.77 | MAPK14 (0.43) | AKT1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5197480 | 0.75 | MAPK14 (0.38) | AKT1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5198429 | 0.75 | MAPK14 (0.43) | AKT1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5199032 | 0.75 | GCGR (0.43) | AKT1MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5194025 | 0.75 | MAPK14 (0.41) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5196158 | 0.75 | LSS (0.34) | MAPK14MAPK13MAPK12MAPK11CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101155796-A | Imidazole derivatives | HOFFMANN LA ROCHE (CH) | 2008-04-02 | — | — | CN | claimed |
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | claimed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | claimed |
| US-20060173048-A1 | Imidazole derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2006-08-03 | — | — | US | claimed |
| CN-101155796-A | Imidazole derivatives | HOFFMANN LA ROCHE (CH) | 2008-04-02 | — | — | CN | disclosed |
| EP-1846389-A1 | IMIDAZOLE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006082002-A1 | IMIDAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173048-A1 | Imidazole derivatives | F. HOFFMAN-LA ROCHE AG (CH) | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173048-A1 | Imidazole derivatives | GRM2, GRM1, GRIN2C | AAK1 1797/4885AKT1 3000/4885MAPK14 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.