Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2395205 | 0.81 | USP2 (0.39) | ATMUSP2SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL16224559 | 0.81 | USP2 (0.39) | ATMUSP2SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL24918232 | 0.81 | USP2 (0.39) | ATMUSP2SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL16224804 | 0.79 | NR1H2 (0.38) | USP2SMN1; SMN2HSD17B10KDM4EMAPT | |
| SCHEMBL1197114 | 0.79 | ATM (0.37) | ATMUSP2SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL5420095 | 0.79 | HSD17B10 (0.42) | USP2SMN1; SMN2HSD17B10KDM4EMAPT | |
| SCHEMBL25374642 | 0.78 | HSD11B1 (0.39) | USP2SMN1; SMN2HSD17B10KDM4EMAPT | |
| SCHEMBL19078479 | 0.78 | ATM (0.41) | ATMUSP2SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL9699056 | 0.76 | PDE4B (0.40) | USP2SMN1; SMN2NR1H2 | |
| SCHEMBL12488098 | 0.76 | ELANE (0.40) | USP2SMN1; SMN2HSD17B10KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814873-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006038006-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |