Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.63 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.63 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.58 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.58 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10208603 | 0.87 | MKNK1 (0.59) | HSD17B10ALDH1A1CYP3A4MKNK1MKNK2 | |
| SCHEMBL30196133 | 0.85 | KDM4E (0.70) | HSD17B10MKNK1MKNK2CYP11B2CYP19A1 | |
| SCHEMBL11342031 | 0.85 | KDM4E (0.70) | HSD17B10MKNK1MKNK2CYP11B2CYP19A1 | |
| Hydrochloric Acid SCHEMBL11336399 | 0.83 | KDM4E (0.68) | HSD17B10MKNK1MKNK2CYP11B2CYP19A1 | |
| SCHEMBL4030646 | 0.82 | S1PR1 (0.67) | HSD17B10ALDH1A1CYP3A4MKNK1MKNK2 | |
| SCHEMBL1232279 | 0.81 | ALDH1A1 (0.71) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL10654961 | 0.81 | MKNK1 (0.59) | HSD17B10MKNK1MKNK2CYP11B2CYP19A1 | |
| Hydrochloric Acid SCHEMBL26978935 | 0.80 | ALDH1A1 (0.91) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL29399235 | 0.80 | ALDH1A1 (1.00) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 | |
| SCHEMBL48945 | 0.80 | ALDH1A1 (1.00) | HSD17B10ALDH1A1CYP3A4TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-8471005-B2 | Pyrrolotriazines as ALK and JAK2 inhibitors | CEPHALON, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | HSD17B10 1879/4885ALDH1A1 779/4885CYP3A4 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.