Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.68 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.65 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.62 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.62 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.61 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.61 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.61 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11342031 | 1.00 | KDM4E (0.70) | KDM4EMAPK1HSD17B10MKNK1MKNK2 | |
| Hydrochloric Acid SCHEMBL11336399 | 0.98 | KDM4E (0.68) | KDM4EMAPK1HSD17B10MKNK1MKNK2 | |
| SCHEMBL4030646 | 0.86 | S1PR1 (0.67) | KDM4EMAPK1HSD17B10MKNK1MKNK2 | |
| SCHEMBL1911847 | 0.86 | NPC1 (0.65) | KDM4EMAPK1HSD17B10MKNK1MKNK2 | |
| SCHEMBL26947690 | 0.85 | CTSD (0.57) | KDM4EMAPK1HSD17B10MKNK1MKNK2 | |
| SCHEMBL30402923 | 0.85 | CTSD (0.57) | KDM4EMAPK1HSD17B10MKNK1MKNK2 | |
| SCHEMBL10208603 | 0.85 | MKNK1 (0.59) | KDM4EMAPK1HSD17B10MKNK1MKNK2 | |
| SCHEMBL4454661 | 0.85 | CYP11B2 (0.66) | KDM4EMAPK1HSD17B10MKNK1MKNK2 | |
| SCHEMBL519862 | 0.85 | HSD17B10 (0.65) | KDM4EMAPK1HSD17B10MKNK1MKNK2 | |
| SCHEMBL10654961 | 0.85 | MKNK1 (0.59) | KDM4EMAPK1HSD17B10MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11559538-B2 | Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors | PFIZER INC. (US) | 2023-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11559538-B2 | Substituted 1,2-oxaborolan-2-ols as PDE4 inhibitors | PDE4B, PDE4A, PDE3B | KDM4E 406/4885MAPK1 379/4885HSD17B10 365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.