Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 8/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198640 | 0.88 | MEN1 (0.54) | MEN1CYP1A2MAPTTSHRKMT2A | |
| SCHEMBL5200187 | 0.86 | MEN1 (0.51) | MEN1CYP1A2MAPTTSHRKMT2A | |
| SCHEMBL5200408 | 0.84 | MAPT (0.51) | MEN1CYP1A2MAPTTSHRKMT2A | |
| SCHEMBL5199044 | 0.83 | MEN1 (0.52) | MEN1CYP1A2MAPTTSHRKMT2A | |
| SCHEMBL2894682 | 0.78 | CYSLTR1 (0.64) | CYP1A2MAPTCYSLTR1CYSLTR2CTSD | |
| SCHEMBL5050181 | 0.77 | CYP1A2 (0.67) | MEN1CYP1A2MAPTTSHRKMT2A | |
| SCHEMBL5200365 | 0.76 | MEN1 (0.48) | MEN1CYP1A2MAPTTSHRKMT2A | |
| SCHEMBL9190362 | 0.76 | MAPT (0.48) | MEN1CYP1A2MAPTTSHRKMT2A | |
| SCHEMBL5200269 | 0.75 | MEN1 (0.48) | MEN1CYP1A2MAPTTSHRKMT2A | |
| SCHEMBL9509183 | 0.74 | MEN1 (0.58) | MEN1CYP1A2MAPTTSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817296-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| EP-1817300-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057860-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |
| WO-2006057869-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |