Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD5 | P21918 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199776 | 1.00 | HTR2C (0.39) | HTR2CHTR2BSIGMAR1DRD1SRD5A1 | |
| Hydrochloric Acid SCHEMBL4132033 | 0.99 | SIGMAR1 (0.39) | HTR2CHTR2BSIGMAR1DRD1SRD5A1 | |
| Hydrochloric Acid SCHEMBL4132036 | 0.99 | SIGMAR1 (0.39) | HTR2CHTR2BSIGMAR1DRD1SRD5A1 | |
| Hydrochloric Acid SCHEMBL4121450 | 0.93 | SIGMAR1 (0.44) | HTR2CHTR2BSIGMAR1KDM1AMAOA | |
| SCHEMBL5198934 | 0.93 | SIGMAR1 (0.44) | HTR2CHTR2BSIGMAR1KDM1AMAOA | |
| Hydrochloric Acid SCHEMBL4121446 | 0.93 | SIGMAR1 (0.44) | HTR2CHTR2BSIGMAR1KDM1AMAOA | |
| SCHEMBL5198931 | 0.93 | SIGMAR1 (0.44) | HTR2CHTR2BSIGMAR1KDM1AMAOA | |
| SCHEMBL4121203 | 0.90 | SIGMAR1 (0.36) | HTR2CHTR2BSIGMAR1DRD1DRD2 | |
| SCHEMBL4121207 | 0.90 | SIGMAR1 (0.36) | HTR2CHTR2BSIGMAR1DRD1DRD2 | |
| SCHEMBL5200282 | 0.85 | SIGMAR1 (0.39) | HTR2CHTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1710240-B1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | SERVIER LAB (FR) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006106241-A1 | PIPERAZINE DERIVATIVES AND USE THEREOF AS SEROTONIN REUPTAKE INHIBITORS OR AS NEUROKININ ANTAGONISTS | LES LABORATOIRES SERVIER (FR) | 2006-10-12 | — | — | WO | disclosed |
| EP-1710240-A1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | Les Laboratoires Servier (FR) | 2006-10-11 | — | — | EP | disclosed |