Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4121203 | 1.00 | SIGMAR1 (0.36) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5770537 | 0.93 | SIGMAR1 (0.39) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL4132226 | 0.93 | SIGMAR1 (0.39) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL4132230 | 0.93 | SIGMAR1 (0.39) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5200282 | 0.93 | SIGMAR1 (0.39) | SIGMAR1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL5199776 | 0.90 | HTR2C (0.39) | SIGMAR1HTR2CHTR2BDRD2DRD1 | |
| SCHEMBL5199775 | 0.90 | HTR2C (0.39) | SIGMAR1HTR2CHTR2BDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL4132033 | 0.89 | SIGMAR1 (0.39) | SIGMAR1HTR2CHTR2BDRD2DRD1 | |
| Hydrochloric Acid SCHEMBL4132036 | 0.89 | SIGMAR1 (0.39) | SIGMAR1HTR2CHTR2BDRD2DRD1 | |
| SCHEMBL5198931 | 0.85 | SIGMAR1 (0.44) | SIGMAR1HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612061-B2 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-11-03 | — | — | US | disclosed |
| US-20090076030-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-03-19 | — | — | US | disclosed |
| US-20090075982-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-03-19 | — | — | US | disclosed |
| US-7465733-B2 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2008-12-16 | — | — | US | disclosed |
| US-20060229318-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2006-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075982-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | SIGMAR1 64/4885HTR3E 121/4885HTR3B 82/4885 |
| US-20090076030-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | SIGMAR1 64/4885HTR3E 121/4885HTR3B 82/4885 |
| US-20060229318-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | SIGMAR1 64/4885HTR3E 121/4885HTR3B 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.