Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27606683 | 0.80 | KDM4E (0.41) | MGAMRAB9AKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL5998390 | 0.79 | KDM4E (0.42) | MGAMRAB9AAKR1C3AKR1C2PDGFRB | |
| SCHEMBL372069 | 0.78 | CYP1A2 (0.44) | MGAMRAB9AKDRACP1PDGFRB | |
| SCHEMBL5462379 | 0.78 | CYP1A2 (0.44) | MGAMRAB9AKDRACP1PDGFRB | |
| SCHEMBL29800505 | 0.78 | CYP1A2 (0.44) | MGAMRAB9AKDRACP1PDGFRB | |
| SCHEMBL846535 | 0.77 | AKR1C3 (0.62) | MGAMRAB9AKDRAKR1C3AKR1C2 | |
| SCHEMBL31016541 | 0.77 | AKR1C3 (0.62) | MGAMRAB9AKDRAKR1C3AKR1C2 | |
| SCHEMBL2631569 | 0.77 | MGAM (0.54) | MGAMRAB9AKDRAKR1C3AKR1C2 | |
| SCHEMBL29029194 | 0.77 | PDGFRB (0.46) | MGAMRAB9AKDRACP1PDGFRB | |
| SCHEMBL30491145 | 0.77 | PDGFRB (0.46) | MGAMRAB9AKDRACP1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262172-B2 | Macrolides | GLAXO GROUP LIMITED (GB) | 2007-08-28 | — | — | US | disclosed |
| EP-1328535-B1 | MACROLIDES | GLAXO GROUP LTD (GB) | 2007-08-15 | — | — | EP | disclosed |
| US-20040254124-A1 | Macrolides | PLIVA D.D. (HR) | 2004-12-16 | — | — | US | disclosed |
| EP-1328535-A1 | MACROLIDES | GLAXO GROUP LIMITED (GB) | 2003-07-23 | — | — | EP | disclosed |
| WO-2002032917-A1 | MACROLIDES | GLAXO GROUP LIMITED (GB) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254124-A1 | Macrolides | OGFOD1, TLR7, MALT1 | MGAM 744/4885RAB9A 3060/4885KDR 4653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.