Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | GFER | P55789 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | KDM1A | O60341 | 3/20 | 0.60 |
| ▸ | TRPC3 | Q13507 | 5/20 | 0.60 |
| ▸ | TRPC6 | Q9Y210 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.55 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2285389 | 0.85 | AMY1A (0.60) | MAPTNPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL4927053 | 0.84 | L3MBTL1 (0.55) | MAPTMAPK1GFERNPC1RAB9A | |
| SCHEMBL525682 | 0.84 | KDM1A (0.76) | MAPTMAPK1NPC1RAB9AGAA | |
| SCHEMBL4919827 | 0.84 | KDM1A (0.76) | MAPTMAPK1GFERNPC1RAB9A | |
| SCHEMBL525812 | 0.84 | KDM1A (0.56) | MAPTMAPK1GFERNPC1RAB9A | |
| SCHEMBL2828892 | 0.84 | MAPT (0.66) | MAPTMAPK1GFERNPC1RAB9A | |
| SCHEMBL525597 | 0.84 | CSNK2A1 (0.65) | MAPTNPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL525271 | 0.83 | KDM1A (0.54) | MAPTMAPK1GFERNPC1RAB9A | |
| SCHEMBL5440976 | 0.82 | CSNK2A1 (0.57) | MAPTNPC1RAB9AGAASMN1; SMN2 | |
| SCHEMBL21708021 | 0.81 | MAPT (0.68) | MAPTMAPK1GFERNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819330-A1 | 5-CARBOXAMIDO SUBSTITUED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE KV FAMILY | Devgen N.V. (BE) | 2007-08-22 | — | — | EP | disclosed |
| WO-2007005785-A1 | THIAZOLES DERIVATIVES AS AMPK ACTIVATOR | DR. REDDY'S LABORATORIES LTD. (IN) | 2007-01-11 | — | — | WO | disclosed |
| WO-2006058905-A1 | 5-CARBOXAMIDO SUBSTITUTED THIAZOLE DERIVATIVES THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE Kv FAMILY | DEVGEN NV (BE) | 2006-06-08 | — | — | WO | disclosed |