Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 17/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 11/20 | 0.50 |
| ▸ | COQ8A | Q8NI60 | 11/20 | 0.50 |
| ▸ | NLK | Q9UBE8 | 11/20 | 0.50 |
| ▸ | EPHB6 | O15197 | 3/20 | 0.50 |
| ▸ | ABL1 | P00519 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.50 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.50 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | TXK | P42681 | 1/20 | 0.46 |
| ▸ | STK16 | O75716 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200512 | 0.83 | EGFR (0.54) | LCKEGFRFLT1FLT4KDR | |
| SCHEMBL7197574 | 0.76 | IMPDH2 (0.58) | GAKRIPK2COQ8ANLKEGFR | |
| SCHEMBL2284106 | 0.73 | IGF1R (0.63) | GAKRIPK2COQ8ANLKEPHB6 | |
| SCHEMBL27601818 | 0.71 | ALDH1A1 (0.58) | — | |
| SCHEMBL23172128 | 0.71 | MAPK10 (0.55) | ABL1EGFRFLT1FLT4KDR | |
| SCHEMBL2572163 | 0.70 | RPS6KA2 (0.63) | JAK2 | |
| SCHEMBL5383253 | 0.70 | TNIK (0.46) | EGFRJAK2CDK2PIK3CAPIK3CB | |
| SCHEMBL13955883 | 0.70 | IGF1R (0.59) | EGFRKDRIGF1RJAK2CDK2 | |
| SCHEMBL10447450 | 0.69 | CYP1A2 (0.41) | — | |
| SCHEMBL1116462 | 0.69 | IGF1R (0.79) | LCKEGFRSRCFLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551813-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-07-11 | — | — | EP | claimed |
| EP-1551813-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-13 | — | — | EP | claimed |
| WO-2004032882-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-22 | — | — | WO | claimed |