Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5206255 | 0.93 | MEN1 (0.41) | MGLLMEN1KMT2AGAAHPGD | |
| SCHEMBL5205796 | 0.89 | HPGD (0.46) | MGLLMEN1KMT2AGAAHPGD | |
| SCHEMBL5262774 | 0.79 | SLC6A9 (0.54) | MEN1KMT2AGAASMN1; SMN2TP53 | |
| SCHEMBL5200358 | 0.78 | SMN1; SMN2 (0.41) | MEN1KMT2AGAAHPGDSMN1; SMN2 | |
| SCHEMBL14064685 | 0.78 | CNR1 (0.53) | GAAHPGDSMN1; SMN2 | |
| SCHEMBL4823367 | 0.78 | CNR1 (0.53) | GAAHPGDSMN1; SMN2 | |
| SCHEMBL4823362 | 0.78 | CNR1 (0.53) | GAAHPGDSMN1; SMN2 | |
| SCHEMBL5201139 | 0.78 | CNR1 (0.53) | GAAHPGDSMN1; SMN2 | |
| SCHEMBL14064687 | 0.78 | CNR1 (0.53) | GAAHPGDSMN1; SMN2 | |
| SCHEMBL4831250 | 0.78 | CNR1 (0.53) | GAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490043-A4 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO INC (US) | 2007-05-30 | — | — | EP | disclosed |
| EP-1490043-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082190-A2 | SPIROCYCLIC AMIDES AS CANNABINOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2003-10-09 | — | — | WO | disclosed |