Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119219 | 0.87 | KDM4E (0.77) | KDM4ENPC1MAPTRAB9AKMT2A | |
| SCHEMBL4105198 | 0.85 | MAPT (0.68) | KDM4ENPC1MAPTRAB9APKM | |
| SCHEMBL5198659 | 0.82 | KDR (0.51) | KDM4ENPC1MAPTRAB9AKMT2A | |
| SCHEMBL4110390 | 0.80 | MEN1 (0.62) | NPC1MAPTRAB9APKMKMT2A | |
| SCHEMBL4112201 | 0.79 | KDM4E (0.54) | KDM4ENPC1MAPTRAB9AKMT2A | |
| SCHEMBL4118526 | 0.79 | MAPT (0.66) | KDM4ENPC1MAPTRAB9AKMT2A | |
| SCHEMBL4122854 | 0.79 | KMT2A (0.56) | KDM4ENPC1MAPTRAB9AKMT2A | |
| SCHEMBL4106008 | 0.79 | NPC1 (0.65) | NPC1MAPTRAB9APKMKMT2A | |
| SCHEMBL4113500 | 0.78 | EPHX2 (0.58) | KDM4EMAPTRAB9AKMT2AMEN1 | |
| SCHEMBL4112050 | 0.77 | RAB9A (0.56) | NPC1MAPTRAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804785-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006049941-A2 | DIARYL UREAS AS CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2006-05-11 | — | — | WO | claimed |