Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 17/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200497 | 0.90 | TGFBR1 (0.67) | TGFBR1MAPK14TDP1RIPK2ACVR1B | |
| SCHEMBL4337360 | 0.81 | TGFBR1 (0.81) | TGFBR1MAPK14TDP1RIPK2ACVR1B | |
| SCHEMBL5200243 | 0.77 | TGFBR1 (0.49) | TGFBR1MAPK14TDP1RIPK2ACVR1B | |
| SCHEMBL5315992 | 0.76 | PIK3CA (0.36) | TGFBR1MAPK14ALDH1A1KDM4EHPGD | |
| SCHEMBL5930811 | 0.72 | TGFBR1 (0.41) | TGFBR1MAPK14TDP1RIPK2ACVR1B | |
| SCHEMBL4337168 | 0.71 | TGFBR1 (0.85) | TGFBR1MAPK14TDP1RIPK2ACVR1B | |
| SCHEMBL4340190 | 0.71 | TGFBR1 (0.81) | TGFBR1MAPK14TDP1RIPK2ACVR1B | |
| SCHEMBL4337372 | 0.71 | TGFBR1 (0.69) | TGFBR1MAPK14TDP1RIPK2ACVR1B | |
| SCHEMBL4339710 | 0.70 | TGFBR1 (1.00) | TGFBR1MAPK14TDP1RIPK2ACVR1B | |
| SCHEMBL29504100 | 0.70 | TGFBR1 (1.00) | TGFBR1MAPK14TDP1RIPK2ACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804801-A2 | METHODS OF TREATING VASCULAR INJURIES | Biogen Idec MA, Inc. (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006044509-A2 | METHODS OF TREATING VASCULAR INJURIES | BIOGEN IDEC MA INC. (US) | 2006-04-27 | — | — | WO | claimed |