Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.31 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314397 | 0.80 | TGFBR1 (0.48) | PIK3CATGFBR1HCRTR1HCRTR2KDM4E | |
| SCHEMBL5201004 | 0.76 | TGFBR1 (0.54) | TGFBR1KDM4EALDH1A1HPGDMAPK14 | |
| SCHEMBL412987 | 0.69 | TGFBR1 (0.45) | TGFBR1 | |
| SCHEMBL5138811 | 0.69 | TGFBR1 (0.49) | TGFBR1MAPK14KDR | |
| SCHEMBL5138513 | 0.68 | TGFBR1 (0.49) | TGFBR1KDM4EALDH1A1MAPK14KDR | |
| SCHEMBL3577722 | 0.66 | CCR1 (0.59) | TGFBR1HCRTR1HCRTR2KDM4EALDH1A1 | |
| SCHEMBL5139156 | 0.66 | TGFBR1 (0.47) | TGFBR1MAPK14KDR | |
| SCHEMBL22347568 | 0.66 | CHRM1 (0.39) | KDM4EALDH1A1HPGDHSD11B1 | |
| SCHEMBL5138562 | 0.65 | TGFBR1 (0.46) | TGFBR1MAPK14 | |
| SCHEMBL5200497 | 0.65 | TGFBR1 (0.67) | TGFBR1ALDH1A1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | disclosed |