Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 9/20 | 0.80 |
| ▸ | NISCH | Q9Y2I1 | 11/20 | 0.53 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200474 | 0.89 | ADRA1A (0.77) | ADRA1ANISCHHTR1AADRA2AADRA2B | |
| Dabuzalgron SCHEMBL5203336 | 0.89 | ADRA1A (1.00) | ADRA1ANISCHHTR1AADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL5203525 | 0.88 | ADRA1A (0.75) | ADRA1ANISCHHTR1AADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL5206476 | 0.88 | ADRA1A (0.62) | ADRA1ANISCHHTR1AADRA2AADRA2B | |
| Dabuzalgron SCHEMBL5200715 | 0.88 | ADRA1A (0.98) | ADRA1ANISCHHTR1AADRA2AADRA2B | |
| Dabuzalgron SCHEMBL19285840 | 0.88 | ADRA1A (0.98) | ADRA1ANISCHHTR1AADRA2AADRA2B | |
| SCHEMBL5202260 | 0.81 | ADRA1A (0.66) | ADRA1ANISCHHTR1AADRA2AADRA2B | |
| SCHEMBL5202963 | 0.81 | ADRA1A (0.60) | ADRA1ANISCHHTR1AADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL5201322 | 0.81 | ADRA1A (0.65) | ADRA1ANISCHHTR1AADRA2AADRA2B | |
| SCHEMBL5201261 | 0.80 | HTR1D (0.59) | ADRA1ANISCHHTR1AADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |
| US-6057349-A | ALPHA.SUB.1A/1L AGONISTS USED IN THE TREATMENT OF VARIOUS DISEASE STATES SUCH AS URINARY INCONTINENCE, NASAL CONGESTION, PRIAPISM, DEPRESSION, ANXIETY, DEMENTIA, SENILITY, ALZHEIMER'S, DEFICIENCIES IN ATTENTIVENESS AND COGNITION, AND | F. HOFFMAN LA ROCHE AG (CH) | 2000-05-02 | — | — | US | disclosed |
| US-5952362-A | INHIBITOR OF GLYCOGEN PHOSPHORYLASE ENZYMETIC ACTIVITY AND GLUCOSE ACITIVITY | SYNTEX (U.S.A) INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | disclosed |