Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 10/20 | 0.55 |
| ▸ | HTR2C | P28335 | 8/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 5/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3152169 | 0.97 | HTR2A (0.58) | HTR2AHTR2CCYP19A1NAMPTKCNH2 | |
| SCHEMBL3172145 | 0.84 | HTR2A (0.78) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL13770798 | 0.74 | HTR2A (0.72) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL3160818 | 0.73 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL3162418 | 0.71 | HTR2A (0.86) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL4069804 | 0.71 | MAOA (0.40) | CYP19A1NAMPTCCR3 | |
| SCHEMBL3159912 | 0.70 | HTR2A (0.57) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL5189735 | 0.65 | HTR2A (0.59) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL3161980 | 0.65 | HTR2A (0.71) | HTR2AHTR2CCYP19A1KCNH2DRD2 | |
| SCHEMBL2474755 | 0.65 | HTR2A (0.59) | HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807393-A1 | DIARYLSULFONES AS 5-HT2A ANTAGONISTS | Merck Sharp & Dohme Limited (GB) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006021805-A1 | DIARYLSULFONES AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2006-03-02 | — | — | WO | disclosed |