Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.58 |
| ▸ | HTR2C | P28335 | 8/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201223 | 0.97 | HTR2A (0.55) | HTR2AHTR2CCYP19A1NAMPTP2RX7 | |
| SCHEMBL3172145 | 0.79 | HTR2A (0.78) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL13770798 | 0.76 | HTR2A (0.72) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL3160818 | 0.75 | HTR2A (1.00) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL3162418 | 0.74 | HTR2A (0.86) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL4069804 | 0.73 | MAOA (0.40) | CYP19A1NAMPTCCR3FBP1 | |
| SCHEMBL3161980 | 0.67 | HTR2A (0.71) | HTR2AHTR2CCYP19A1KCNH2DRD2 | |
| SCHEMBL3167199 | 0.66 | HTR2A (0.74) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL5212638 | 0.66 | HTR2A (0.67) | HTR2AHTR2CKCNH2DRD2 | |
| SCHEMBL3159912 | 0.66 | HTR2A (0.57) | HTR2AHTR2CKCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807393-B1 | DIARYLSULFONES AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME (GB) | 2010-03-31 | — | — | EP | disclosed |
| US-20090170824-A1 | Diarylsulfones as 5-HT2A Antagonists | CASTRO PINEIRO JOSE LUIS | 2009-07-02 | — | — | US | disclosed |
| US-7468393-B2 | Diarylsulfones as 5-HT2A antagonists | MERCK SHARP & DOHME LTD. (GB) | 2008-12-23 | — | — | US | disclosed |
| US-20070203205-A1 | Diarylsulfones as 5-HT2A antagonists | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2007-08-30 | — | — | US | disclosed |
| US-7217740-B2 | Diarylsulfones as 5-HT2A antagonists | MERCK SHARP AND DOHME | 2007-05-15 | — | — | US | disclosed |
| US-20060052445-A1 | Diarylsulfones as 5-HT2A antagonists | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203205-A1 | Diarylsulfones as 5-HT2A antagonists | HTR2A, HTR2B, HTR1A | HTR2A 1/4885HTR2C 4/4885CYP19A1 902/4885 |
| US-20060052445-A1 | Diarylsulfones as 5-HT2A antagonists | HTR2A, HTR2B, HTR1A | HTR2A 1/4885HTR2C 4/4885CYP19A1 902/4885 |
| US-20090170824-A1 | Diarylsulfones as 5-HT2A Antagonists | HTR2A, HTR2B, HTR1A | HTR2A 1/4885HTR2C 4/4885CYP19A1 902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.